Rational choice of hepatoprotectors for drug-induced liver injury
نویسندگان
چکیده
The article deals with a review of the current literature on clinical use hepatoprotectors in drug-induced liver injury. was searched Scopus, Web Science, PubMed and other databases. Risk factors, pathogenetic mechanisms liver damage, international diagnostic criteria treatment for injuries are considered. Clinical pharmacological approaches to choice management injury substantiated. positive effects ademetionine, hepatoprotector, highlighted — choleretic, cholekinetic, regenerating, antioxidant antitoxic. In accordance principles evidence-based medicine, it has been found that indisputable advantage ademetionine comprehensive is its high effectiveness as mean cholestasis, hepatocellular lesions their combinations.
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1Office of Computational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA 2Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany 3Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA 4Division of Bioinformatics and Biostatistics, National Center for Toxicological Research,...
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ژورنال
عنوان ژورنال: ?????????????????
سال: 2022
ISSN: ['2384-101X', '2672-1163']
DOI: https://doi.org/10.22141/2308-2097.56.3.2022.507